Two new Macrostomum genomes

We have just published two new Macrostomum genome assemblies!

Macrostomum flatworms - free-living and simultaneously hermaphroditic creatures - have become increasingly important models for studying regeneration, reproduction, and stem-cell function. The genome of M. lignano, the only species with a published genome assembly in this group, has paved the way for significant progress. However, its hidden polyploid nature - a result of recent whole-genome duplication and chromosome fusion events - presents significant challenges, often limiting the application of modern genetic tools.

Responding to this need, we present robust genomic resources for M. cliftonense and M. hystrix, the two species that represent the genus’ contrasting mating behaviors: reciprocal copulation and hypodermic insemination, respectively. By employing a combination of PacBio long-read sequencing and Illumina shot-gun sequencing, along with several RNA-Seq datasets, we have managed to assemble and annotate highly contiguous genomes for both species.

Both species have smaller genomes (227Mb and 220Mb) than M. lignano (764Mb) making them excellent targets for genetic work.

You can find the publication here.